Red Dragon is the 2002 feature film prequel to 1991's The Silence of the Lambs. Directed by Brett Ratner (Rush Hour), the film stars Edward Norton as former FBI Special Agent Will Graham and Anthony Hopkins, reprising his Academy-Award winning role of Dr. Hannibal Lecter. Red Dragon is the second feature film adaptation of the Thomas Harris book of the same name - which was actually the first to feature Lecter, as Michael Mann had previously adapted the material into the 1986 film Manhunter.
The following weapons were used in the film Red Dragon:
Smith & Wesson 459
The Smith & Wesson 459 is the sidearm of FBI Special Agent Will Graham (Edward Norton) at the beginning of the film. He is seen drawing it from a shoulder holster as Lecter stabs him. Graham is also seen preparing one for the raid on Dolarhyde's house. The FBI purchased 803 S&W 459's and issued it to agents in the early eighties. The second generation 459 was manufactured from 1979-1987. Since the film begins in 1980, Graham's 459 would be consistent. He is seen carrying the S&W in his holster for the rest of the film. Additionally the F.B.I. authorized agent to carry privately purchased handguns from a list of pre-approved handguns. The agents would have to have the handgun checked out by an Bureau armorer and any repairs or modifications would have to be done by one of the armorers. It isn't implausible that Graham's Model 459 is his property.
Smith & Wesson Model 49 Bodyguard
Graham (Edward Norton) carries a Smith & Wesson Model 49 as his backup gun in an ankle holster. He draws it when Lecter continues to come after him. The Model 49 Bodyguard was authorized by the FBI for carry in 1972. (See American Rifleman September 2011; Draw & Fire: A History of FBI Handguns by Bill Vanderpool.)
Colt Detective Special
A post-1972 (3rd Generation) Colt Detective Special is used by Will Graham (Edward Norton) at the end of the movie when he engages in a shootout with Francis Dolarhyde aka The Tooth Fairy (Ralph Fiennes) after he invades the Graham home. Graham's wife Molly (Mary-Louise Parker) also is seen taking target practice with it.
Another weapon Graham keeps in his home is the Walther PPK. He grabs it along with the Colt as he locks himself and his son in his bedroom. Molly is seen using it as well.
Ted Williams Model 21 Deluxe (sawed off)
A cut-down Ted Williams Model 21 is used by the Tooth Fairy (Ralph Fiennes) when he is contemplating suicide, and later, when the FBI arrive at his house. The same gun or one very close to it was used in The Punisher (2004). He mentions that it is "a 12 Gauge Police Magnum Shotgun," apparently referring to the Remington 870 Police Magnum, though the shotgun in the movie is not a Remington.