Assassin's Creed: Brotherhood
The following weapons appear in the video game Assassin's Creed Brotherhood:
Due being set for most part in Renaissance Italy; the game is the first of the series to feature guns as commonplace; while Assassin's Creed II allowed the player to use a hidden gun; guns start to appear as cannons and as small arms in enemy hands. However unlike the Hidden Gun from the previous game, they can't be used by Ezio.
Heckler & Koch Mark 23 Phase II Prototype
The Raiden Outfit is inspired by the Metal Gear Solid 4 Raiden model, which has a holstered Heckler & Koch Mark 23 pistol. As before, this pistol is never drawn, not even when Ezio use the hidden gun. Since the outfit is unlocked by completing VR Training Session, it can be used as early as reaching Rome, in 1500; making the gun anachronistic by circa 491 years.
1560 Wheellock Mace
Octavian de Valois' personal gun is based on the German wheellock mace made circa 1560 which is in the collection of the Royal Armouries.
Wheellock Pistols are utilized by the Papal Guard and by Cesare Borgia.
The "Hidden Gun" is a fictional firearm device used by Ezio.
Various factions in game use wheellock arquebuses.
Medieval bombard cannons are a common sight in the game seen in use by the various factions, including the player. They are used by both sides at the Siege of Monteriggioni and Ezio also uses one later against Leonardo's tanks.
Smaller caliber cannons are used with Leonardo's tanks.
Da Vinci's Machinegun
A multibarreled machine gun developed by Leonardo da Vinci appears, mounted on a chariot. It's design consists basically in a wheel with multiple guns. Despite the name has a very slow rate of fire. Albeit the scientist designed a machine gun (albeit more akin to a volley gun) in real life called "Organo a 33 canne", Da Vinci's design is fictional in the game.
The naval cannon is a fictional weapon designed by Leonardo in the game.