Fear and Loathing in Las Vegas

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Fear and Loathing in Las Vegas is a 1998 film, set in the early 1970's, directed by Terry Gilliam, starring Benicio Del Toro as Oscar Z. Acosta (with the alias in the film of Dr. Gonzo) along with Johnny Depp as Hunter S. Thompson (Playing under the name of his pen name of Raoul Duke). It follows Duke and Gonzo through Las Vegas, whilst under the influence of every hallucinogenic drug known to mankind. The film is based on (the real) Hunter S. Thompson's novel of the same name.

Smith and Wesson Model 19

The main gun seen in the film, referred to as a "357", is held by both characters in the film, and is only fired by Duke in the latter stages of the film.

Dr. Gonzo points the unloaded weapon at Duke while he is consuming cocaine.

Duke stares at the Model 19 whilst holding mace after being woken up by room service.

Essential items...

Duke prepares to fire the Model 19

Hunting Shotguns

Seen briefly in the hands of three spectators by Duke when he is covering the motorbike race in the desert of Nevada.

Three men firing shotguns possibly at targets off screen.

M16

Seen briefly in archive footage of the Vietnam War at various times during the film.

Also seen later in the film, in a similar fashion, is a nondescript rocket launcher and a distorted aircraft bomber.

M16A?

Highly likely that these are later M16's mocked up to look like an earlier model.

Gun toting enthusiasts pop in to say a quick hello...

A girl uses an M16 in an attraction at "Bazooko's Circus" casino, possibly with a 30 round magazine.

M60 Machine Gun

Seen mounted on a Jeep by gun toting hunters/spectators during Duke's attempt at covering the motorcycle race.